Methocarbamol interactions with gabapentin

Lidocan Patch disease interactions. There are 5 disease interactions with Lidocan Patch (lidocaine topical) which include: teething pain. cardiovascular dysfunction. hepatic dysfunction. renal dysfunction. seizures.

Applies to: Morphine Sulfate ER (morphine) and gabapentin. Using narcotic pain or cough medications together with other medications that also cause central nervous system depression such as gabapentin can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns.The LactMed® database contains information on drugs and other chemicals to which breastfeeding mothers may be exposed. It includes information on the levels of such substances in breast milk and infant blood, and the possible adverse effects in the nursing infant. Suggested therapeutic alternatives to those drugs are provided, where appropriate. All data are derived from the scientific ...Methocarbamol should be used with caution in those prescribed multiple central nervous system (CNS) depressants, benzodiazepines, opioids, and those who have known substance use …Carbidopa/levodopa Interactions. There are 483 drugs known to interact with carbidopa/levodopa, along with 12 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 46 are major, 426 are moderate, and 11 are minor.Summary: Drug interactions are reported among people who take Dilaudid and Gabapentin. Common interactions among females include abdominal pain and arthralgia. Common interactions among males include anxiety and nausea. The phase IV clinical study analyzes what interactions people have when they take Dilaudid and Gabapentin together.Metaxalone is a muscle relaxant used to treat muscle pain or spasm. Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®.

Ferslew KE, Hagardorn AN, McCormick WF "A fatal interaction of methocarbamol and ethanol in an accidental poisoning." J Forensic Sci 35 (1990): 477-82 Plushner SL "Valerian: valeriana officinalis." ... Gabapentin GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. ...Drug Interactions between Neurontin and Robaxin-750. This report displays the potential drug interactions for the following 2 drugs: Neurontin (gabapentin) Robaxin-750 (methocarbamol) Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs. ModerateHYDROmorphone gabapentin. Applies to: hydromorphone and gabapentin. Using narcotic pain or cough medications together with other medications that also cause central nervous system depression such as gabapentin can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or ...The LactMed® database contains information on drugs and other chemicals to which breastfeeding mothers may be exposed. It includes information on the levels of such substances in breast milk and infant blood, and the possible adverse effects in the nursing infant. Suggested therapeutic alternatives to those drugs are provided, where appropriate. All data are derived from the scientific ...Zuclopenthixol. Both Morphine and Zuclopenthixol can cause sedation, which might affect the ability to perform skilled tasks (see 'Drugs and Driving' in Guidance on Prescribing ). See the list of drugs that interact with Morphine. Includes information on severity of interaction and the level of evidence for it.Orphenadrine Interactions. There are 393 drugs known to interact with orphenadrine, along with 1 disease interaction, and 1 alcohol/food interaction. Of the total drug interactions, 32 are major, 360 are moderate, and 1 is minor.

If necessary, Lyrica can be used in treatment of epilepsy (combined with other medications), fibromyalgia and in complex therapy of generalized disturbs. Buy Lyrica Pregabalin online without prescription Lyrica 300 mg, 150 mg, 75 mg. This medication is used to treat pain caused by nerve damage due to diabetes, shingles (herpes zoster) infection, or spinal …Robaxin, also known as methocarbamol, is a muscle relaxant medication used to treat muscle pain and tightness caused by strains, sprains, or other muscle injuries. It works by blocking nerve impulses that transmit pain signals to the brain, providing relief from muscle discomfort. Robaxin is available in the form of tablets, with commonly ...Bottom Line. Tips. Response/effectiveness. Interactions. 1. How it works. Methocarbamol is a muscle relaxant that may be used in addition to other treatments for …This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. If you are taking certain long-acting formulations of hydrocodone, consumption of ...Using propranolol together with multivitamin with minerals may decrease the effects of propranolol. Separate the administration times of propranolol and multivitamin with minerals by at least 2 hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications.

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methocarbamol HYDROcodone. Applies to: methocarbamol and hydrocodone. Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns.Summary: Drug interactions are reported among people who take Prednisone and Robaxin. Common interactions among females include foot fracture and fatigue. Common interactions among males include pain and dizziness. The phase IV clinical study analyzes what interactions people have when they take Prednisone and Robaxin together.Horizant (gabapentin enacarbil) is an extended release tablet used to treat restless legs syndrome and for the pain from having shingles (postherpetic nerve pain). Generic brands of gabapentin capsules, USP are used for postherpetic nerve pain and for add on therapy for partial onset seizures in patients 3 years and older. WarningsAspirin and methocarbamol may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking aspirin and methocarbamol. Also, in combination with aspirin, alcohol can be damaging to the stomach.Common interactions include bronchitis among females and arthralgia among males. The phase IV clinical study analyzes what interactions people who take Methocarbamol and Lidocaine have. It is created by eHealthMe based on reports of 304 people who take Methocarbamol and Lidocaine from the FDA, and is updated regularly.Some tizanidine interactions should be avoided entirely. But others may only require closer monitoring. Below, we'll cover five of the most important tizanidine interactions you should know. 1. Medications that increase tizanidine levels. Tizanidine is metabolized (broken down) in the liver.

Interaction Details. As discussed above, both Robaxin and Benadryl have central nervous system depressant effects. Taking them together may cause additive CNS depression (e.g. sedation, dizziness). If you have been directed to take both by your doctor, you may need to adjust the dose of either or both medications.Methocarbamol (Robaxin) is an oral medication used to treat muscle pain and stiffness. Learn about side effects, warnings, dosage, and more. ... Interactions that increase the risk of side effects.Overall, 12.3% of case patients (155 of 1256) and 6.8% of control patients (313 of 4619) were prescribed gabapentin in the 120 days preceding the index date.Common interactions among females include hypoaesthesia and headache. Common interactions among males include chronic kidney disease and renal failure. The phase IV clinical study analyzes what interactions people have when they take Methocarbamol and Amoxicillin together. It is created by eHealthMe based on data from the FDA, and is updated ...Methocarbamol has moderate interactions with at least 150 different drugs. Mild Interactions of methocarbamol include: eucalyptus; sage; This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and ...Socala et al. 42 observed that CBD increased the activity of topiramate, oxcarbazepine, pregabalin, tiagabine, and gabapentin, but did not affect the anticonvulsant effect of lamotrigine and lacosamide. Increased anticonvulsant activity of AEDs was partly related to pharmacokinetic interactions with CBD because CBD increased serum and brain ...Common side effects of Skelaxin vs. Flexeril. Both drugs can be very sedating. Skelaxin's most common side effects are drowsiness, dizziness, headache, irritability, nausea, vomiting, and stomach upset. The most common side effects of Flexeril are drowsiness, dizziness, headache, and dry mouth. With either drug, an allergic reaction is rare ...The phase IV clinical study analyzes what interactions people have when they take Methocarbamol and Flexeril together. It is created by eHealthMe based on data from the FDA, and is updated regularly. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world.The combined use of Xanax and Gabapentin can lead to heightened cognitive impairment and memory problems. Individuals may experience difficulty concentrating, confusion, and memory loss. These effects can be detrimental to daily functioning and quality of life. Increased Sedation and Dizziness: Mixing Xanax and Gabapentin can intensify sedation ...Applies to: amitriptyline and gabapentin. Using amitriptyline together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol ...

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. Major: Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Moderate

Methocarbamol Tablets USP, 500 mg, 750 mg, and 1000 mg, a carbamate derivative of gualfenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties. The chemical name of methocarbamol is a 3- (2 methoxyphenoxy)-1,2-propanediol 1-carbamate and has the empirical formula C11H15NO5.Overall, 12.3% of case patients (155 of 1256) and 6.8% of control patients (313 of 4619) were prescribed gabapentin in the 120 days preceding the index date.sertraline methocarbamol. Applies to: Zoloft (sertraline) and Robaxin (methocarbamol) Using sertraline together with methocarbamol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.Applies to: gabapentin. Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin. Do not use more than the recommended dose ...Methocarbamol Interactions With Gabapentin. When considering the potential interactions between Methocarbamol and Gabapentin, it's crucial to know how they may affect each other when used together. Here are some key points to keep in mind: Sedation: Methocarbamol and Gabapentin can cause drowsiness and central nervous system depression. They ...A doctor has provided 1 answer. can you take trimadol. meloxicam. and gabapentin together it was prescribed for back pain from scoliosis: Potentially: Tramadol is a mild pain medication, Meloxicam is an antii.Applies to: Klonopin (clonazepam) and gabapentin. Using clonazePAM together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of ...Applies to: gabapentin and Zanaflex (tizanidine) Using tiZANidine together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of ...gabapentin traMADol. Applies to: gabapentin and tramadol. Using narcotic pain or cough medications together with other medications that also cause central nervous system depression such as gabapentin can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns.Zuclopenthixol. Both Methocarbamol and Zuclopenthixol can cause sedation, which might affect the ability to perform skilled tasks (see 'Drugs and Driving' in Guidance on Prescribing ). See the list of drugs that interact with Methocarbamol. Includes information on severity of interaction and the level of evidence for it.

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The list below does not include all possible drug interactions with Methocarbamol. Please note that only the generic name of each medication is listed below. More on Methocarbamol interactions. 5 Methocarbamol Interactions You Should Know About ... Gabapentin is a great remedy for nerve pain, and it's sometimes prescribed for back pain too. ...Applies to: gabapentin. Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin. Do not use more than the recommended dose ...Mar 5, 2021 · Methocarbamol is a medication used in the management and treatment of acute musculoskeletal pain. It is in the skeletal muscle relaxant class of medications. This activity reviews the indications, mechanism of action, and contraindications for methocarbamol as an option in the multimodal treatment of acute musculoskeletal pain. This activity will also underscore critical factors to consider ... Methocarbamol (Robaxin) is an oral medication used to treat muscle pain and stiffness. Learn about side effects, warnings, dosage, and more. ... Interactions that increase the risk of side effects.strong painkillers, such as morphine - these can make you very tired and dizzy when you start taking gabapentin. antidepressants, such as amitriptyline or fluoxetine. antipsychotic medicines for mental health problems like schizophrenia or bipolar disorder. a medicine to prevent malaria called mefloquine.Lidocan Patch disease interactions. There are 5 disease interactions with Lidocan Patch (lidocaine topical) which include: teething pain. cardiovascular dysfunction. hepatic dysfunction. renal dysfunction. seizures.Applies to: gabapentin. Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin. Do not use more than the recommended … Robaxin, also known as methocarbamol, is a muscle relaxant medication used to treat muscle pain and tightness caused by strains, sprains, or other muscle injuries. It works by blocking nerve impulses that transmit pain signals to the brain, providing relief from muscle discomfort. Robaxin is available in the form of tablets, with commonly ... Methocarbamol should be used with caution in those prescribed multiple central nervous system (CNS) depressants, benzodiazepines, opioids, and those who have known substance use disorders. Methocarbamol should not be used in patients with myasthenia gravis taking acetylcholinesterase inhibitors.Gabapentin (Neurontin) is a medication that’s used to treat seizures and nerve pain. Magnesium is a mineral that’s important for your health. When a magnesium-containing medication or supplement is … ….

Metaxalone is used to help relax the muscles in your body and relieve the discomfort caused by acute (short-term), painful muscle or bone conditions. However, this medicine does not take the place of rest, exercise, physical therapy, or other treatments that your doctor may recommend for your condition. Metaxalone is a skeletal muscle relaxant.Zuclopenthixol. Both Morphine and Zuclopenthixol can cause sedation, which might affect the ability to perform skilled tasks (see 'Drugs and Driving' in Guidance on Prescribing ). See the list of drugs that interact with Morphine. Includes information on severity of interaction and the level of evidence for it.These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. Major: Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. ModeratePeople react to their environment in a variety of ways. The environment sometimes shape these interactions. Sustainability efforts exist to help humans co-exist peacefully with the...There is no known drug interaction between methocarbamol and non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac. You may take methocarbamol and diclofenac together. Because it may cause drowsiness or dizziness, methocarbamol interacts with other drugs that have similar effects, such as alcohol and drugs that treat sleep disorders.propranolol methocarbamol. Applies to: propranolol and methocarbamol. Propranolol and methocarbamol may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment ...oxyCODONE gabapentin. Applies to: oxycodone and gabapentin. Using narcotic pain or cough medications together with other medications that also cause central nervous system depression such as gabapentin can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns.Common side effects of Skelaxin vs. Flexeril. Both drugs can be very sedating. Skelaxin's most common side effects are drowsiness, dizziness, headache, irritability, nausea, vomiting, and stomach upset. The most common side effects of Flexeril are drowsiness, dizziness, headache, and dry mouth. With either drug, an allergic reaction is rare ... Methocarbamol interactions with gabapentin, OBJECTIVE: To determine whether duloxetine is noninferior to (as good as) pregabalin in the treatment of pain associated with diabetic peripheral neuropathy. PATIENTS AND METHODS: We performed a 12-week, open-label study of patients with diabetic peripheral neuropathic pain who had been treated with gabapentin (≥900 mg/d) and had an inadequate response (defined as a daily pain score of ≥4 ..., methocarbamol + baclofen intrathecal. monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects) Find medical information for methocarbamol on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures., Applies to: baclofen and gabapentin. Using baclofen together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being ..., fever; confusion, problems with memory; nausea, vomiting, upset stomach; blurred vision, double vision; flushing (warmth, redness, or tingly feeling); sleep problems (insomnia); or. lack of ..., Common interactions among males include chronic kidney disease and renal failure. The phase IV clinical study analyzes what interactions people have when they take Prednisone and Methocarbamol together. It is created by eHealthMe based on data from the FDA, and is updated regularly. Phase IV trials are used to detect adverse drug outcomes and ..., Common interactions among males include chronic kidney disease and renal failure. The phase IV clinical study analyzes what interactions people have when they take Meloxicam and Methocarbamol together. It is created by eHealthMe based on data from the FDA, and is updated regularly. Phase IV trials are used to detect adverse drug outcomes and ..., The main types are: Drug-drug interaction. This is when a medication reacts with one or more other drugs. For example, taking a cough medicine ( antitussive) and a drug to help you sleep (sedative ..., These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. Major: Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Moderate, Aug 22, 2023 ... Tapentadol, a centrally-acting analgesic, can also interact dangerously with Gabapentin. The resulting increased risk of CNS depression and ..., Zaleplon Interactions. There are 411 drugs known to interact with zaleplon, along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 28 are major, and 383 are moderate., Gabapentin dosing ... Muscle relaxants — We avoid ongoing use of the drugs referred to as muscle relaxants (eg, methocarbamol, metaxalone, carisoprodol) for patients with chronic pain. A wide variety of pain conditions may be accompanied by painful muscles, and at times spasm. ... For specific interactions, use the drug interactions program ..., Older adults who take gabapentin also are at higher risk of breathing problems. Because gabapentin can enhance the psychological effect of opioids, it has the potential to be abused and has contributed to drug overdose deaths. Drugs such as gabapentin have been linked in rare cases to an increased risk of suicidal thoughts or …, More about Tylenol ( acetaminophen ) Ratings & Reviews. Gabapentin has an average rating of 7.1 out of 10 from a total of 2513 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 21% reported a negative effect. Tylenol has an average rating of 5.9 out of 10 from a total of 31 ratings on Drugs.com. 50% of reviewers reported ..., gabapentin food. Applies to: gabapentin. Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin., Gabapentin is an anticonvulsant medication used to treat nerve pain and anxiety. Muscle relaxers, on the other hand, are prescribed to relieve muscle spasms and stiffness. Both medications work differently and can be prescribed together in certain situations. However, it is important to note that combining drugs can increase the risk of side ..., 7. Interactions. Medicines that interact with cyclobenzaprine may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with cyclobenzaprine. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does., Key takeaways: Tramadol (Ultram, ConZip, Qdolo) is an opioid medication used to treat pain. It has many possible drug interactions, including some antidepressants, antibiotics, and diuretics. Some tramadol interactions raise the risk of side effects of tramadol. Examples include sleepiness, an increased risk of seizures, or serotonin …, Dilantin Interactions. There are 833 drugs known to interact with Dilantin (phenytoin), along with 12 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 225 are major, 563 are moderate, and 45 are minor. ... gabapentin, clonazepam, lamotrigine, lorazepam, pregabalin, topiramate, diazepam, Ativan, Valium ..., These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. Major: Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Moderate, Additional potential pharmacodynamic interactions were identified in sensitivity analyses: methocarbamol, temazepam, and quetiapine combined with methadone; and morphine combined with buprenorphine. In the pharmacokinetic screening analysis, we identified two moderate to strong potential DDIs mediated through CYP-enzyme inhibition (clonidine ..., Methocarbamol . Methocarbamol is an oral and parenteral centrally acting muscle relaxant indicated as an adjunct to physical therapy for the relief of acute musculoskeletal pain. Similar to many medications in this class, the exact mechanism of action is unknown, but its effects may be due to general CNS depression., Tizanidine interactions to avoid. Several drug interactions are associated with the use of tizanidine. Medications that increase the effects of tizanidine may cause increased drowsiness or lightheadedness to occur. Tizanidine hydrochloride is a skeletal muscle relaxant. Zanaflex is the brand name, while tizanidine is the generic version of this ..., Gabapentin has an average rating of 7.1 out of 10 from a total of 2514 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 21% reported a negative effect. Meloxicam has an average rating of 6.2 out of 10 from a total of 596 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 34% reported a negative effect., methocarbamol food. Alcohol can increase the nervous system side effects of methocarbamol such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with methocarbamol. Do not use more than the recommended dose ..., Gabapentin is an anticonvulsive medication that is primarily used to treat seizures and nerve pain. It was initially developed as a muscle relaxer and anti-spasmodic medication, but its anticonvulsive properties were discovered later. Gabapentin is also used as an adjunct to more potent anticonvulsants and for the management of certain types of ... , Methocarbamol and Gabapentin are both used to ease pain, particularly lower back pain. In terms of interaction, taking Methocarbamol and Gabapentin together has been shown to result in increased severity of adverse effects including intense drowsiness, lack of focus, confusion, increased risk for injury, depression, and suicidal thoughts. Side ..., Sep 16, 2022 ... 13:45 · Go to channel · #054 Ten Questions about GABAPENTIN (Neurontin) for pain: uses, dosages, and risks. Dr. Andrea Furlan•742K views · 7:0..., morphine gabapentin. Applies to: morphine and gabapentin. Using narcotic pain or cough medications together with other medications that also cause central nervous system depression such as gabapentin can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns., Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin. Do not use more than the recommended dose of gabapentin, and avoid ... , Plavix (clopidogrel) is a brand-name oral tablet prescribed to help lower the risk of heart attack and stroke in certain adults. Plavix has interactions with some other drugs and certain supplements., Drug interactions are reported among 1,284 peopel who take Gabapentin and Robaxin. Common interactions among females include chest pain and insomnia. Common interactions among males include drug ineffective and anxiety. ... Robaxin has active ingredients of methocarbamol. It is used in muscle spasms. Currently, eHealthMe is …, Tylenol with Codeine #1 Interactions. There are 573 drugs known to interact with Tylenol with Codeine #1 (acetaminophen / codeine), along with 19 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 131 are major, 429 are moderate, and 13 are minor., The Earth’s four spheres interact in all six possible combinations: lithosphere and hydrosphere, lithosphere and biosphere, lithosphere and atmosphere, hydrosphere and biosphere, h...